Nashan, Dorothee and Mueller, Marcel Lucas and Braun-Falco, Markus and Reichenberger, Sebastian and Szeimies, Rolf-Markus and Bruckner-Tuderman, Leena (2009) Cutaneous metastases of visceral tumours: a review. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 135 (1). pp. 1-14. ISSN 0171-5216, 1432-1335
Full text not available from this repository. (Request a copy)Abstract
Background Up to 10% of all visceral malignancies develop cutaneous metastases. As cutaneous metastases are underestimated and underdiagnosed they can be a clinical challenge. The clinical appearance and patterns of distribution of cutaneous metastases, the characterisation of clinical outcomes and available therapeutic options are compiled. Patients and methods Literature ( over the last 6 years) MESH in terms of cutaneous metastases was comprehensively evaluated. Characteristics from 92 available cases are elaborated and adjusted with terms ( time unlimited) of published epidemiological reviews to single organs. Results The broad clinical spectrum with differential diagnoses is displayed. An allocation of cutaneous metastases and a particular organ is not reliable. In 22% of all cases cutaneous metastases can lead to the diagnosis of an internal malignoma. The majority of cases reveal cutaneous metastases to emerge in a tumour-free interval in about 36 months, after a successful treatment of the primary tumour, most commonly along with other organ metastases. Probable survival turned out to be less than 12 months. Consistently with this end-stage condition, treatment aligns with rules of palliation. Local treatment of choice is excision. Only a minority of investigators attempted to come up with tumour-specific treatment strategies, and almost no randomised therapy studies can be presented. Conclusion A reference guide of cutaneous metastases is given; the clinical spectrum is adjusted to an actual status; state of the art of the treatment is accomplished. An epidemiological, improved registration and diagnostic work-up for targeted therapies in conjunction with dermatologists are favoured.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OF-THE-LITERATURE; RENAL-CELL CARCINOMA; FOLLICULAR THYROID-CARCINOMA; UNUSUAL CLINICAL PRESENTATION; MARY-JOSEPH-NODULE; SKIN METASTASES; HEPATOCELLULAR-CARCINOMA; GASTRIC ADENOCARCINOMA; INTERNAL MALIGNANCY; EPIDERMOTROPIC METASTASES; Dermatology; Neoplasm metastasis; Skin neoplasms; Review (publication type); Therapeutics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 19 Oct 2022 09:51 |
| Last Modified: | 19 Oct 2022 09:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29759 |
Actions (login required)
 |
View Item |
