Lindner, Juha and Noutsias, Michel and Lassner, Dirk and Wenzel, Juergen and Schultheiss, Heinz-Peter and Kuehl, Uwe and Modrow, Susanne (2009) Adaptive immune responses against parvovirus B19 in patients with myocardial disease. JOURNAL OF CLINICAL VIROLOGY, 44 (1). pp. 27-32. ISSN 1386-6532, 1873-5967
Full text not available from this repository. (Request a copy)Abstract
Background: Parvovirus B19 (B19V)-DNA is frequently detected in endomyocardial biopsies (EMBs) from patients with acute myocarditis (AMC) and dilated cardiomyopathy (DCM), but also in various healthy tissues. The clinical relevance of this DNA-persistence is unclear. Objectives: To investigate potential pathogenic influences of B19V-DNA in EMBs, we analyzed B19V-specific adaptive immune responses in AMC/DCM patients and healthy controls. Study design: 15 AMC/DCM patients with detectable B19V-DNA in EMBs and 51 controls were analyzed for signs of acute B19V-infections and virus-specific immune responses by PCR, ELISA, Western line, and ELISpot-assays. Results: Productive B19V-infection was determined in three patients. Slightly lower levels of B19V-specific T-cells were observed in patients as compared to the controls, no differences were observed in virus-specific serology. Viral DNA-load in EMBs could not be correlated to the number of B19V-specific T-cells. No differences in T-cell response, viremia and/or serological markers indicative for viral pathogenesis were observed in patients with inflammatory cardiomyopathy. Conclusions: Discrepancies in B19V-specific adaptive immunity were not observed in AMC/DCM patients as compared to controls. The data indicate that the exclusive detection of B19V-DNA in EMBs is not sufficient to associate B19V with AMC/DCM but should be complemented with additional virological and immunological parameters in further studies. (c) 2008 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DILATED CARDIOMYOPATHY; TRANSPLANT RECIPIENT; HIGH PREVALENCE; VIRAL GENOMES; INFECTION; PERSISTENCE; DNA; DYSFUNCTION; INFARCTION; BIOPSY; Parvovirus B19; Cellular immune response; Humoral immune response; Cardiomyopathy; Myocarditis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Oct 2020 11:02 |
| Last Modified: | 12 Oct 2020 11:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29762 |
Actions (login required)
 |
View Item |
