Fenzl, Christoph and Hirsch, Thomas and Baeumner, Antje J. (2016) Nanomaterials as versatile tools for signal amplification in (bio)analytical applications. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 79. pp. 306-316. ISSN 0165-9936, 1879-3142
Full text not available from this repository. (Request a copy)Abstract
(Bio)analytical applications often require efficient signal enhancement strategies that are directly integrated into the biorecognition process. Nanomaterials are increasingly used for this purpose, as their small size provides numerous unique properties. This review identifies recent trends in (bio)analytical sensing and discusses the use of nanomaterials as signal enhancement tags and as carriers in enzymatic amplification enabling significantly higher performance compared to traditional assays. Gold nanoparticles are one of the most established amplification tools and still play a major role in the development of highly sensitive (bio)assays. These are based on signal enhancement for detection approaches that range from colorimetric over plasmonic and electrochemical to mass spectrometric systems. We also discuss the opportunities of other nanomaterials such as nanocomposites including carbon nanotubes and graphene, magnetite nanoparticles, polymeric nanomaterials, liposomes and quantum dots that are increasingly used in this field. Based on the observed trends, future perspectives in (bio)assay development are presented. (C) 2015 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SURFACE-PLASMON RESONANCE; LINKED-IMMUNOSORBENT-ASSAY; HIGHLY SENSITIVE DETECTION; PROTEIN-KINASE ACTIVITY; QUANTUM DOTS LABELS; BOVINE-MILK SAMPLES; GOLD-NANOPARTICLE; ULTRASENSITIVE DETECTION; ELECTROCHEMICAL IMMUNOASSAY; IMMUNOCHROMATOGRAPHIC ASSAY; (Bio)analytical sensing; Electrochemical; Enzymatic; Immunoassay; Label; Nanomaterial; Nanoparticle; Optical; Signal amplification; Surface plasmon resonance |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 01 Sep 2020 08:49 |
| Last Modified: | 01 Sep 2020 08:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/2977 |
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