Schierling, Wilma and Troidl, Kerstin and Troidl, Christian and Schmitz-Rixen, Thomas and Schaper, Wolfgang and Eitenmueller, Inka K. (2009) The Role of Angiogenic Growth Factors in Arteriogenesis. JOURNAL OF VASCULAR RESEARCH, 46 (4). pp. 365-374. ISSN 1018-1172, 1423-0135
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Background/Aims: Collateral vessels restore only about 40% of the maximum dilatory reserve after femoral artery occlusion, whereas complete normalization is reached by increased fluid shear stress (FSS). We studied the role of known potent angiogenic growth factors (separately or in combination) in arteriogenesis by determining their expression in FSS-stimulated collaterals and close-to-collateral infusion of growth factor peptides in a rabbit model of femoral artery occlusion. Methods: Values of maximum collateral conductance (C max) and post mortem angiograms were compared to those achievable by high FSS. mRNA levels of growth factor ligands and receptors were determined in FSS-stimulated collaterals. Results: Seven days after vessel occlusion, FSS-stimulated legs showed a C max not significantly different from that of not occluded femoral arteries. Arteriogenesis was significantly less enhanced after growth factor treatment (MCP-1 86%, Ad5.1-FGF-4 75%, bFGF 72%, PDGF 64%, VEGF 50% of C max after FSS stimulation). RT-PCR showed no differential expression of FGF receptors, but an up-regulation of VEGF-receptor-2. Conclusion: The most potent known angiogenic growth factors at high pharmacological doses reach only a fraction of the maximum conductance obtained by high FSS. Arteriogenesis differs from angiogenesis, so the main focus to markedly improve arteriogenesis should be put on the underlying mechanisms of shear stress. Copyright (C) 2009 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FEMORAL-ARTERY OCCLUSION; NITRIC-OXIDE SYNTHASE; FLUID SHEAR-STRESS; ACTIVITY IN-VIVO; RABBIT HINDLIMB; GENE-TRANSFER; PROTEIN THERAPY; BLOOD-FLOW; EXPRESSION; ISCHEMIA; Arteriogenesis; Growth factors; Shear stress; Gene transfer; Hemodynamics; Receptors |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Oct 2020 07:37 |
| Last Modified: | 13 Oct 2020 07:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29799 |
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