Zeitz, O. and Berna-Thill, M. and Bartsch, U. and Strauss, O. and Richard, G. (2009) Oxidativer Stress am retinalen Pigmentepithel – experimentelle Ansätze zur Protektion = Oxidative Stress at the Retinal Pigment Epithelium - Experimental Implications for Protection. KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE, 226 (1). pp. 27-30. ISSN 0023-2165
Full text not available from this repository. (Request a copy)Abstract
Oxidative stress at the retinal pigment epithelium (RPE) is involved in the pathophysiology of age-related macula degeneration (ARMD). Observations on a clinical or laboratory level have revealed that supplementation of antioxidative scavengers failed in many cases. A potential therapeutic target is the cellular signal transduction cascade initiated by oxidative stress which results, e.g., in altered expression of pro- and antiagiogenic factors as well as induction of apoptosis. This review summarises the current literature on cellular effects of free radicals and deduces potential therapeutic approaches to protect the RPE from oxidative damage.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR-H POLYMORPHISM; HUMAN RPE CELLS; MACULAR DEGENERATION; DIABETIC-RETINOPATHY; VITAMIN-C; ERYTHROPOIETIN; LIPOFUSCIN; VEGF; APOPTOSIS; DAMAGE; Retina; Pharmacology; Pathology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Petra Gürster |
| Date Deposited: | 19 Oct 2022 08:13 |
| Last Modified: | 19 Oct 2022 08:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29800 |
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