Dreiseitel, Andrea and Schreier, Peter and Oehme, Anett and Locher, Sanja and Rogler, Gerhard and Piberger, Heidi and Hajak, Goeran and Sand, Philipp G. (2009) ANTHOCYANINS AND ANTHOCYANIDINS ARE POOR INHIBITORS OF CYP2D6. METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, 31 (1). pp. 3-9. ISSN 0379-0355, 2013-0155
Full text not available from this repository. (Request a copy)Abstract
The cytochrome P450 CYP2D6 isoform is involved in the metabolism of about 50% of oil psychoactive drugs, including neuroleptic agents, selective serotonin reuptake inhibitors, selective norepinephrine reuptake inhibitors and tricyclic antidepressants. Therefore, inhibition of cytochrome P450 activity by foodstuffs has implications for drug safety. The present study addresses inhibitory effects of polyphenolic anthocyanins and their aglycons that are found in many dietary fruits and vegetables. Using a chemiluminescent assay, we obtained IC50. values ranging from 55 mu M to > 800 mu M for 77 individual compounds. According to earlier data on furanocoumarins from grapefruit extract, CYP2D6 inhibition is achieved in the range of 190-900 nM. As the tested anthocyanins and anthocyonidins were shown to be about 1,000-fold less potent, they ore unlikely to interfere with drug metabolism by CYP2D6. Further studies are warranted to examine the effects of the above flavonoids on other CYP isoforms for more detailed toxicity profiles.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ST-JOHNS-WORT; HUMAN LIVER-MICROSOMES; HERB-DRUG INTERACTIONS; GRAPEFRUIT JUICE; IN-VITRO; CYTOCHROME-P450 ENZYMES; RED WINE; BOTANICAL SUPPLEMENTATION; ANTIPSYCHOTIC-DRUGS; CLINICAL-ASSESSMENT; Cytochrome P450; Flavonoid; Anthocyanin; Anthocyanidin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Oct 2020 06:05 |
| Last Modified: | 13 Oct 2020 06:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29806 |
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