Agaimy, Abbas and Wuensch, Peter H. and Hofstaedter, Ferdinand and Schroeder, Josef (2009) Hyaline globules in paucicellular leiomyomas of the gastrointestinal tract are distinct from skeinoid fibers and represent degenerating smooth muscle cells. PATHOLOGY RESEARCH AND PRACTICE, 205 (6). pp. 417-422. ISSN 0344-0338,
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Skeinoid fibers are globular, brightly eosinophilic periodic Schiff stain (PAS)-positive extracellular collagen deposits commonly seen in gastrointestinal stromal tumors (GIST) of the small bowel. However, smooth-surfaced hyaline globules are occasionally encountered in leiomyomatous GI neoplasms and may be mistaken for true skeinoid fibers. We investigated a total of 93 histologically and immunohistochemically well-characterized true smooth muscle neoplasms of the GI tract for the presence of hyaline globules. A variable number of PAS-positive intracellular and interstitial hyaline globules were detected in all benign paucicellular leiomyomas of the muscularis mucosae (n = 72) and the muscularis propria (n = 14) irrespective of tumor size and site, but in none of leiomyosarcomas (n = 7) and cellular leiomyoma (n = 1). In addition, similar findings were rarely seen in the adjacent muscularis propria. Similar to surrounding tumor cells, hyaline globules expressed desmin, alpha-SMA, and h-caldesmon, but were negative for CD 117 and CD34. Ultrastructural examination revealed altered filamentous material in different stages of degeneration with variably condensed matrix and occasional peripheral condensation suggestive of calcification. True skeinoid fibers were not detected. The above findings are consistent with a multistep degenerative phenomenon affecting individual smooth muscle cells in paucicellular GI leiomyomas. Awareness of this finding would prevent misinterpretation as GIST, particularly in small biopsies. (C) 2009 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTESTINAL STROMAL TUMORS; EOSINOPHILIC GLOBULES; UTERINE LEIOMYOMAS; FEATURES; Leiomyoma; Gastrointestinal; Hyaline globules; Skeinoid fibers; GIST |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Oct 2020 14:56 |
| Last Modified: | 13 Oct 2020 14:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29829 |
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