Steinbauer, Julia Maria and Schreml, Stephan and Babilas, Philipp and Zeman, Florian and Karrer, Sigrid and Landthaler, Michael and Szeimies, Rolf-Markus (2009) Topical photodynamic therapy with porphyrin precursors-assessment of treatment-associated pain in a retrospective study. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 8 (8). pp. 1111-1116. ISSN 1474-905X, 1474-9092
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Photodynamic therapy (PDT) with aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) is an approved modality for the non-invasive treatment of actinic keratoses (AK)and basal cell carcinoma (BCC) offering excellent cosmetic outcome. However, pain during and after illumination is the most frequent and limiting side effect. The aim of this study was to precisely assess how reported pain during PDT is influenced by sex, age, treatment site, disease (AK/BCC) as well as the photosensitizer used. 467 lesions consisting of AK (primary treatments: n=158; follow-up: n=47) or BCC (primary treatments: n=138; follow-up: 124) were treated by ALA- or MAL-PDT using metal halide lamps (580-750 nm). Pain was assessed during illumination using a continuous visual analogue scale (VAS). Factors predictive for higher pain levels during PDT are treatment of the head, treating AK and using ALA. The observed results may improve patient management and predict which level of pain to expect, and what kind of pain relief to prepare.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DELTA-AMINOLEVULINIC-ACID; ACTINIC KERATOSES; 5-AMINOLEVULINIC ACID; METHYL AMINOLEVULINATE; BOWENS-DISEASE; DOUBLE-BLIND; NORMAL SKIN; MULTICENTER; DERMATOLOGY; THRESHOLDS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Oct 2020 15:04 |
| Last Modified: | 13 Oct 2020 15:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29857 |
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