Bubl, Emanuel and Van Elst, Ludger Tebartz and Gondan, Matthias and Ebert, Dieter and Greenlee, Mark W. (2009) Vision in depressive disorder. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 10 (4). pp. 377-384. ISSN 1562-2975, 1814-1412
Full text not available from this repository. (Request a copy)Abstract
Background. Reduced dopaminergic transmission has been implicated in the pathophysiology of major depression. Furthermore, dopaminergic neurotransmission plays an important role in the physiology of visual contrast sensitivity (CS). To test the hypothesis that altered dopaminergic neurotransmission plays a role in major depression we measured contrast sensitivity in patients with major depression and in healthy control subjects. Methods. Twenty-eight patients diagnosed with major depressive disorder were compared to 21 age-matched control subjects on their ability to detect a Gabor target with slightly elevated luminance contrast embedded in seven equi-contrast distracters. Results. Contrast discrimination thresholds were significantly elevated in unmedicated and medicated patients with major depression compared to control subjects, at all pedestal contrast levels tested. Conclusions. Contrast discrimination performance is reduced in depressive patients and might reflect a state of altered dopaminergic neurotransmission.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SPATIOTEMPORAL CONTRAST SENSITIVITY; PARKINSONS-DISEASE; DOPAMINE RELEASE; MAJOR DEPRESSION; DISCRIMINATION; MEMORY; PSYCHOPHYSICS; INVOLVEMENT; DEFICIENCY; PERCEPTION; Depressive disorder; contrast sensitivity; dopamine; schizophrenia |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie I (Allgemeine Psychologie I und Methodenlehre) - Prof. Dr. Mark W. Greenlee |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Oct 2020 06:04 |
| Last Modified: | 14 Oct 2020 06:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29896 |
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