Siroen, Michiel P. C. and Wiest, Reiner and Richir, Milan C. and Teerlink, Tom and Rauwerda, Jan A. and Drescher, Friedrich T. and Zorger, Niels and van Leeuwen, Paul A. M. (2008) Transjugular intrahepatic portosystemic shunt-placement increases arginine/asymmetric dimethylarginine ratio in cirrhotic patients. WORLD JOURNAL OF GASTROENTEROLOGY, 14 (47). pp. 7214-7219. ISSN 1007-9327, 2219-2840
Full text not available from this repository. (Request a copy)Abstract
AIM: To analyze the change of dimethylarginine plasma levels in cirrhotic patients receiving transjugular intrahepatic portosystemic shunt (TIPS). METHODS: To determine arginine, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and nitric oxide (NO) plasma levels, blood samples were collected from the superior cava, hepatic, and portal vein just before, directly after, and 3 mo, after TIPS-placement. RESULTS: A significant increase in the arginine/ADMA ratio after TIPS placement was shown. Moreover, TIPS placement enhanced renal function and thereby decreased systemic SDMA levels. In patients with renal dysfunction before TIPS placement, both the arginine/ADMA ratio and creatinine clearance rate increased significantly, while this was not the case in patients with normal renal function before TIPS placement. Hepatic function did not change significantly after TIPS placement and no significant decline in ADMA plasma levels was measured. CONCLUSION: The increase of the arginine/ADMA ratio after TIPS placement suggests an increase in intracellular NO bioavailability. In addition, this study suggests that TIPS placement does not alter dimethylarginine dimethylaminohydrolase (DDAH) activity and confirms the major role of the liver as an ADMA clearing organ. (C) 2008 The WJG Press. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NITRIC-OXIDE SYNTHASE; PORTAL HYPERTENSIVE-RATS; ASYMMETRIC DIMETHYLARGININE; SYMMETRIC DIMETHYLARGININE; MONOCLONAL-ANTIBODY; PLASMA; LIVER; ADMA; DIMETHYLAMINOHYDROLASE; N(G)-DIMETHYLARGININE; Asymmetric dimethylarginine; Symmetric dimethylarginine; Arginine; Liver cirrhosis; Transjugular intrahepatic portosystemic shunt |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Oct 2020 08:34 |
| Last Modified: | 14 Oct 2020 08:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29922 |
Actions (login required)
 |
View Item |
