Klein, Christoph A. (2008) The direct molecular analysis of metastatic precursor cells in breast cancer: A chance for a better understanding of metastasis and for personalised medicine. EUROPEAN JOURNAL OF CANCER, 44 (18). pp. 2721-2725. ISSN 0959-8049, 1879-0852
Full text not available from this repository. (Request a copy)Abstract
The search for disseminated cancer cells has become a routine procedure in many clinical centres since the pioneering work of Riethmuller and Schlimok was published in the mid 1980s. Until today, clinical studies have mostly focused on the prognostic role of disseminated cancer cells that can be detected in bone marrow samples before manifestation of metastasis. As a more recent development, the field is increasingly concentrating on the prognostic information provided by tumour cells circulating in the peripheral blood instead of analysing the nature of disseminated tumour cells that have successfully homed to a new microenvironment and may eventually grow into metastases. This review critically questions that direction and proposes exploiting the unique opportunities provided by the direct molecular analysis of metastatic precursor cells for a better understanding of metastasis, tumour dormancy, therapy target identification, and personalised medicine in an adjuvant therapy setting. (C) 2008 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISSEMINATED TUMOR-CELLS; CYTOKERATIN-POSITIVE CELLS; BONE-MARROW; STEM-CELLS; PROGNOSTIC-SIGNIFICANCE; MONOCLONAL-ANTIBODIES; COLORECTAL-CANCER; PANCREATIC-CANCER; RANDOMIZED-TRIAL; GENETIC-ANALYSIS; Breast cancer; Micrometastasis; Metastasis; Disseminated tumour cell; Circulating tumour cell |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Oct 2020 09:54 |
| Last Modified: | 14 Oct 2020 09:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29952 |
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