Wolff, Johannes E. A. and Kramm, Christof and Kortmann, Rolf-Dieter and Pietsch, Torsten and Rutkowski, Stefan and Jorch, Norbert and Gnekow, Astrid and Driever, Pablo Hernaiz (2008) Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma. JOURNAL OF NEURO-ONCOLOGY, 90 (3). pp. 309-314. ISSN 0167-594X,
Full text not available from this repository. (Request a copy)Abstract
Valproic acid (VPA) inhibits histone deacetylase and has been reported to induce apoptosis in glioma. We report 44 heavily pretreated pediatric patients with high-grade glioma or diffuse intrinsic pontine glioma who received VPA as oral continues maintenance treatment with individual dose adaptation. The tumor status when starting the drug was: no measurable disease in 12, measurable but stable disease in 12, and measurable progressive disease in 22 patients. Average trough blood levels of VPA were 99 mg/l. The most frequent complaint was somnolence (three patients), but no severe toxicity was reported. One relapse patient responded, early progression of disease was observed in three frontline patients and in six relapsed patients. Median overall survival duration for all patients was 1.33 years, with large differences between first-line (5-year overall survival, 44%) and relapse therapy (5-year overall survival, 14%). This shows that valproate is safe in this patient population. The moderate tumor efficacy encourages studying the drug further as an element of multi-agent protocols.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HISTONE DEACETYLASE INHIBITOR; SUBEROYLANILIDE HYDROXAMIC ACID; ACTIVITY IN-VITRO; PHASE-I; MALIGNANT GLIOMA; HIT-GBM; SIMULTANEOUS RADIOCHEMOTHERAPY; GLIOBLASTOMA-MULTIFORME; FETAL-HEMOGLOBIN; TOPOISOMERASE-II; Valproic acid; Glioblastoma; Anaplastic astrocytomas; Pontine glioma; Child; Adolescent |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Oct 2020 05:08 |
| Last Modified: | 19 Oct 2020 05:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/29984 |
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