Blana, Andreas and Rogenhofer, Sebastian and Ganzer, Roman and Lunz, Jens-Claudio and Schostak, Martin and Wieland, Wolf F. and Walter, Bernhard (2008) Eight Years' Experience With High-Intensity Focused Ultrasonography for Treatment of Localized Prostate Cancer. UROLOGY, 72 (6). pp. 1329-1333. ISSN 0090-4295,
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OBJECTIVES To report on the long-term results of high-intensity focused Ultrasonography (HIFU) in the treatment of localized prostate cancer. METHODS Patients with clinical Stage T1-T2N0M0, biopsy-proven, localized prostate cancer, with a serum prostate-specific antigen (PSA) level of <= 20 ng/mL, Gleason score of <= 7, and with no previous curative prostate cancer treatment, were included. All patients underwent HIFU using the Ablatherm device and were required to have a minimal follow-up of 3 years after the last HIFU session to be included in this analysis. Follow-up included PSA measurement and biopsy performed 3-6 months after treatment and in conjunction with an increasing PSA level. Biochemical failure was defined according to the Phoenix definition (PSA nadir + 2 ng/mL). In determining the disease-free Survival rate, treatment was considered to have failed if any of the following Occurred: biochemical failure, positive biopsy findings, or the initiation of salvage treatment. RESULTS The study included 163 patients. Within the 4.8 +/- 1.2 years of follow-up, no patient died of prostate cancer. Of the 163 patients, 86.4% achieved a PSA nadir of <1 ng/mL and 92.7% had negative post-treatment biopsy findings. The actuarial biochemical Survival rate at 5 years was 75%. The actuarial disease-free Survival rate at 5 years was 66%, with salvage treatment initiated for 12% of the patients. On multivariate analysis, the pretreatment PSA level was the only statistically significant predictive factor of recurrence (P = .005). CONCLUSIONS The results after long-term follow-up have indicated that HIFU is an efficient and safe treatment for patients with localized prostate cancer. UROLOGY 72: 1329-1333, 2008.(C) 2008 Published by Elsevier Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BEAM RADIATION-THERAPY; RADICAL PROSTATECTOMY; ULTRASOUND; IMPLANTATION; RADIOTHERAPY; OUTCOMES; FAILURE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Oct 2020 05:50 |
| Last Modified: | 19 Oct 2020 05:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30026 |
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