Selleng, Sixten and Haneya, Assad and Hirt, Stephan and Selleng, Kathleen and Schmid, Christof and Greinacher, Andreas (2008) Management of anticoagulation in patients with subacute heparin-induced thrombocytopenia scheduled for heart transplantation. BLOOD, 112 (10). pp. 4024-4027. ISSN 0006-4971, 1528-0020
Full text not available from this repository. (Request a copy)Abstract
Anticoagulation management of patients with recent heparin-induced thrombocytopenia (HIT) requiring cardiopulmonary bypass (CPB) surgery is a serious challenge, and especially difficult in patients requiring urgent heart transplantation. As nonheparin anticoagulants during CPB bear a high risk of major bleeding, these patients are at risk of being taken off the transplant list. Short-term use of unfractionated heparin (UFH) for CPB, with restriction of UFH to the surgery itself, is safe and effective in patients with a history of HIT who test negative for antiplatelet factor 4 (PF4)/heparin antibodies. We present evidence that it is safe to expand the concept of UFH reexposure to patients with subacute HIT (ie, those patients with recent HIT in whom the platelet count has recovered but in whom antiPF4/heparin IgG antibodies remain detectable) requiring heart transplantation, if they test negative by a sensitive functional assay using washed platelets. This can be lifesaving in patients with end-stage heart failure. (Blood. 2008; 112: 4024-4027)
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OPTICAL-DENSITY VALUES; CARDIOPULMONARY BYPASS; ANTI-PF4/HEPARIN ANTIBODIES; CLINICAL-SIGNIFICANCE; CARDIAC-SURGERY; HISTORY; IGG; REEXPOSURE; DIAGNOSIS; ELISA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Oct 2020 05:50 |
| Last Modified: | 19 Oct 2020 05:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30052 |
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