Reinhard, Wibke and Stark, Klaus and Sedlacek, Kamil and Fischer, Marcus and Baessler, Andrea and Neureuther, Katharina and Weber, Stefan and Kaess, Bernhard and Wiedmann, Silke and Mitsching, Stefan and Lieb, Wolfgang and Erdmann, Jeanette and Meisinger, Christa and Doering, Angela and Tolle, Ralf and Jeron, Andreas and Riegger, Guenter and Hengstenberg, Christian (2008) Association between PPAR alpha gene polymorphisms and myocardial infarction. CLINICAL SCIENCE, 115 (9-10). pp. 301-308. ISSN 0143-5221,
Full text not available from this repository. (Request a copy)Abstract
PPAR alpha (peroxisome-proliferator-activated receptor alpha) regulates the expression of genes that are involved in lipid metabolism, tissue homoeostasis and inflammation. Consistent rodent and human studies suggest a link between PPAR alpha function and cardiovascular disease, qualifying PPAR alpha [PPARA in HUGO (Human Genome Organisation) gene nomenclature] as a candidate gene for coronary artery disease. In the present study, we comprehensively evaluated common genetic variations within the PPAR alpha gene and assessed their association with myocardial infarction. First, we characterized the linkage disequilibrium within the PPAR alpha gene in an initial case-control sample of 806 individuals from the Regensburg Myocardial Infarction Family Study using a panel of densely spaced SNPs (single nucleotide polymorphisms) across the gene. Single SNP analysis showed significant association with the disease phenotype [OR (odds ratio) = 0.74, P = 0.012, 95% CI (confidence interval) = 0.61-0.94 for rs135551]. Moreover, we identified a protective three-marker haplotype with an association trend for myocardial infarcition (OR = 0.76, P = 0.067, 95% CI = 0.56-1.02). Subsequently, we were able to confirm the single SNP and haplotype association results in an independent second case-control cohort with 667 cases from the Regensburg Myocardial Infarction Family Study and 862 control individuals from the WHO (World Health Organization) MONICA (Monitoring of Trends and Determinants in Cardiovascular Disease) Augsburg project (OR = 0.87, P = 0.046, 95% CI = 0.72-0.99 for rs135551 and OR = 0.80, P = 0.034, 95% CI = 0.65-0.98 for the three-marker haplotype respectively). From these cross-sectional association results, we provide evidence that common variations in the PPAR alpha gene may influence the risk of myocardial infarcition in a European population.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROLIFERATOR-ACTIVATED RECEPTOR; CORONARY-HEART-DISEASE; HUMAN ENDOTHELIAL-CELLS; RISK-FACTORS; HAPLOTYPE RECONSTRUCTION; L162V POLYMORPHISM; ARTERY-DISEASE; LIPID MEASURES; CHOLESTEROL; POPULATION; cardiovascular risk; case-control study; gene polymorphism; myocardial infarction; peroxisome-proliferator-activated receptor alpha (PPAR alpha) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Oct 2020 08:46 |
| Last Modified: | 19 Oct 2020 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30081 |
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