Ettl, T. and Schwarz, Stephan and Kleinsasser, N. and Hartmann, A. and Reichert, T. E. and Driemel, O. (2008) Overexpression of EGFR and absence of C-KIT expression correlate with poor prognosis in salivary gland carcinomas. HISTOPATHOLOGY, 53 (5). pp. 567-577. ISSN 0309-0167,
Full text not available from this repository. (Request a copy)Abstract
Aims: To evaluate the prognostic impact of expression of receptor tyrosine kinases epidermal growth factor receptor (EGFR), HER2, and C-KIT in relation to established clinicopathological parameters in salivary gland carcinomas. Methods and results: Immunohistochemistry for EGFR, HER2, C-KIT and the proliferation marker Ki67 was performed in 101 cases of salivary gland carcinoma and related to long-term clinical follow-up. Immunopositivity of C-KIT was common in adenoid cystic carcinoma (92%). Lack of C-KIT expression occurred in salivary duct carcinoma (P < 0.001) and was associated with high-grade tumours (P = 0.002), positive lymph nodes (P = 0.002) and high expression of Ki67 (P = 0.001). HER2 was typically expressed in salivary duct carcinomas (83%), but was not associated with any other parameter. EGFR overexpression occurred independently of histological type and clinical parameters. On univariate survival analysis, overexpression of EGFR (P = 0.011) and lack of C-KIT (P = 0.014) were associated with worse prognosis, whereas HER2 was of no prognostic significance. On multivariate analysis, the strongest negative predictor of survival was high proliferative activity measured by Ki67 (P = 0.002), followed by presence of residual tumour (P = 0.006), overexpression of EGFR (P = 0.026) and advanced tumour stage (P = 0.041). Conclusions: The expression of receptor tyrosine kinases confers additional prognostic impact on disease-specific survival. EGFR overexpression is an independent negative prognostic factor.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADENOID CYSTIC CARCINOMA; EPIDERMAL-GROWTH-FACTOR; EX PLEOMORPHIC ADENOMA; ACINIC CELL CARCINOMAS; FACTOR RECEPTOR; PAROTID-GLAND; MUCOEPIDERMOID CARCINOMA; IMATINIB MESYLATE; PARAFFIN SECTIONS; MIB-1 ANTIBODY; C-KIT; EGFR; Ki67; prognostic factors; salivary gland cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Oct 2020 10:02 |
| Last Modified: | 19 Oct 2020 10:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30100 |
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