Breyer, Johannes and Gierth, Michael and Shalekenov, Sanzhar and Aziz, Atiqullah and Schafer, Julius and Burger, Maximilian and Denzinger, Stefan and Hofstadter, Ferdinand and Giedl, Christian and Otto, Wolfgang (2016) Epithelial-mesenchymal transformation markers E-cadherin and survivin predict progression of stage pTa urothelial bladder carcinoma. WORLD JOURNAL OF UROLOGY, 34 (5). pp. 709-716. ISSN 0724-4983, 1433-8726
Full text not available from this repository. (Request a copy)Abstract
To determine whether the immunohistochemical markers survivin and E-cadherin can predict progress at initially diagnosed Ta bladder cancer. We retrospectively searched for every initially diagnosed pTa urothelial bladder carcinoma having been treated at our single-center hospital in Germany from January 1992 up to December 2004. Follow-up was recorded up to June 2010, with recurrence or progress being the endpoints. Immunohistochemical staining and analysis of survivin and E-cadherin of the TURB specimens were performed. Outcome dependency of progression and no progression with immunohistochemical staining was analyzed using uni- and multivariate regression analysis, Kaplan-Meier analysis and uni- and multivariate Cox regression analysis. Overall, 233 patients were included. Forty-two percent of those were tumor free in their follow-up TURBs, 46 % had at least one pTa recurrence and 12 % even showed progress to at least pT1 bladder cancer. Aberrant staining of E-cadherin was found within 71 % of patients with progression in contrast to only 40 % in cases without progression (p = 0.004). Of all progressed patients, 92 % showed overexpression of survivin in their initial pTa specimen compared to 61 % without progression (p = 0.001). Kaplan-Meier analysis revealed aberrant E-cadherin staining to be associated with worse progression-free survival (PFS) (p = 0.005) as well as overexpression of survivin (p = 0.003). In multivariate Cox regression analysis, strong E-cadherin staining was an independent prognosticator for better PFS (p = 0.033) and multifocality (p = 0.046) and tumor size over 3 cm (p = 0.042) were prognosticators for worse PFS. Adding the immunohistochemical markers survivin and E-cadherin could help to identify patients at risk of developing a progressive disease in initial stage pTa bladder cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSITIONAL-CELL CARCINOMA; PROGNOSTIC MARKER; CANCER STATISTICS; ALPHA-CATENIN; BETA-CATENIN; IN-SITU; EXPRESSION; RECURRENCE; SNAIL; Non-muscle-invasive bladder cancer; Immunohistochemistry; Survivin; E-cadherin; EMT; Stage pTa bladder cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2019 12:24 |
| Last Modified: | 25 Mar 2019 12:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3011 |
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