Rivera, Francisco J. and Kandasamy, Mahesh and Couillard-Despres, Sebastien and Caioni, Massimiliano and Sanchez, Rosario and Huber, Christophe and Weidner, Norbert and Bogdahn, Ulrich and Aigner, Ludwig (2008) Oligodendrogenesis of adult neural progenitors: differential effects of ciliary neurotrophic factor and mesenchymal stem cell derived factors. JOURNAL OF NEUROCHEMISTRY, 107 (3). pp. 832-843. ISSN 0022-3042,
Full text not available from this repository. (Request a copy)Abstract
The oligodendrogenic program of progenitor cells in the adult CNS follows a sequential process of progenitor proliferation, fate choice, determination, differentiation, maturation and survival. Previously, we described a soluble activity derived from mesenchymal stem cells that induces oligodendrogenesis in adult neural progenitor cells. Here, we hypothesized that ciliary neurotrophic factor might be a candidate for this activity, since (i) it is expressed by mesenchymal stem cells and (ii) it can promote oligodendrogenesis during development. Along the course of the study, we found differential effects by ciliary neurotrophic factor and by the mesenchymal stem cells-derived activity on neural progenitors. While the mesenchymal stem cells-derived activity induced oligodendrogenesis at the expense of astrogenesis and promoted oligodendroglial differentiation/maturation, the effect of ciliary neurotrophic factor was restricted to the latter one. This was reflected at the levels of the cell fate determinants Olig1, Olig2, Id2, and the oligodendroglia-maturation transcription factor GTX/Nkx6.2. Finally, experiments using blocking antibodies excluded ciliary neurotrophic factor to be the mesenchymal stem cell-derived oligodendroglial activity. In summary, this work provides evidence for differential effects of ciliary neurotrophic factor and mesenchymal stem cells-derived activity on oligodendrogenesis of adult neural progenitor cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM; IN-VITRO; CNTF; VIVO; OLIGODENDROCYTES; BRAIN; ASTROGLIOGENESIS; NEUROGENESIS; REGENERATION; POTENTIATION; neural progenitors; mesenchymal stem cells; oligodendrocyte differentiation; ciliary neurotrophic factor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Oct 2020 06:32 |
| Last Modified: | 21 Oct 2020 06:32 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30113 |
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