Fraunberger, Peter and Holler, Ernst and Parhofer, Klaus G. and Wallli, Autar K. and Seidel, Dietrich (2008) Interleukin 6, procalcitonin and CRP levels during first increase of fever in intensive care patients. LABORATORIUMSMEDIZIN-JOURNAL OF LABORATORY MEDICINE, 32 (6). pp. 434-437. ISSN 0342-3026, 1439-0477
Full text not available from this repository. (Request a copy)Abstract
Serum levels of interleukin 6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) were measured in 38 critically ill patients immediately after an increase in body temperature above 38.3 degrees C. Ten healthy controls were also included for comparison. The onset of fever was accompanied by elevated circulating levels of all the 3 markers in comparison to healthy control subjects. However, only IL-6 levels were significantly higher (p<0.05) in nonsurvivors compared with survivors. Sensitivity, specificity, positive, and negative predictive values for survival were higher for IL-6 in comparison to levels of PCT and CRP. Areas under receiver characteristic operating curves revealed the highest area under the curve for IL-6 compared to PCT and CRP. These data suggest that IL-6 rather than PCT or CRP may be an early predictor of prognosis and mortality in patients with the onset of fever.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BACTERIAL-INFECTION; SEPSIS; CIRRHOSIS; MARKER; SHOCK; cytokines; fever; infection; procalcitonin; prognosis; sepsis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Oct 2020 06:49 |
| Last Modified: | 21 Oct 2020 06:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30122 |
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