Brechenmacher, S. A. and Bruns, C. J. and Van den Engel, N. K. and Angele, P. and Loehe, F. and Jauch, K. -W. and Angele, Martin K. (2008) Influence of surgical trauma on the mRNA expression of sex hormone receptors in PBMCs in male and female patients. LANGENBECKS ARCHIVES OF SURGERY, 393 (6). pp. 871-876. ISSN 1435-2443, 1435-2451
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Introduction Gender-specific immune responses have been found after trauma-hemorrhage. Male and female sex hormones seem to be responsible for this gender dimorphism. Alterations in sex hormone receptor expression in mice appear to contribute to the immunomodulatory effect of sex hormones after blood loss. The effect of surgical trauma on the expression of sex hormone receptors in peripheral blood mononuclear cells (PBMCs) from patients, however, remains unknown. Materials and methods PBMCs were obtained from 14 patients (7 men and 7 women) undergoing major abdominal surgery preoperatively and 2 h postoperatively. The expression of the androgen and the estrogen alpha- and beta- receptors were determined by reverse transcriptase polymerase chain reaction (RT-PCR). beta-Actin was used as housekeeping gene. Results The results indicate that surgical trauma has no influence on the expression of the androgen receptor and the estrogen receptors alpha and beta in male and female patients. Discussion The data demonstrate that, in contrast to mice, no alterations in the expression of androgen and estrogen hormone receptors were evident after surgery in patients. Thus, differences in the expression of sex hormone receptors do not appear to be responsible for the gender-specific immune response after surgery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMMUNE-RESPONSES; ANDROGEN RECEPTOR; CYTOKINE RELEASE; GENE-EXPRESSION; BREAST-CANCER; HEMORRHAGE; ESTROGEN; TESTOSTERONE; MACROPHAGES; SEPSIS; gender specific immune response; surgical patients; estrogen receptor; androgen receptor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Oct 2020 07:01 |
| Last Modified: | 21 Oct 2020 07:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30123 |
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