Beule, Achim G. and Scharf, Christian and Biebler, Karl-Ernst and Goepferich, Achim and Steinmeier, Elke and Wolf, Eduard and Hosemann, Werner and Kaftan, Holger (2008) Effects of Topically Applied Dexamethasone on Mucosal Wound Healing Using a Drug-Releasing Stent. LARYNGOSCOPE, 118 (11). pp. 2073-2077. ISSN 0023-852X,
Full text not available from this repository. (Request a copy)Abstract
Objective/Hypothesis: Evaluation of the impact of continuously topically released dexamethasone using a drug-releasing stent on quality of regenerated mucosa after full thickness injury in the paranasal sinuses. Study Design: Prospective, controlled, randomized, double-blinded animal study. Methods: Nineteen New Zealand white rabbits were subjected to surgery: via an external approach, a 4 mm circular wound was created on the medial side of the maxillary sinus. The wound was covered in a randomized fashion with either a silicone foil or a new drug releasing stent system. Twelve to 30 days later, the animals were killed and histology and electron microscopy were performed. One animal was used for baseline comparisons at day 0. Results: No animals were lost due to infection or dislocation of the stent, leaving 18 animals for evaluation of postoperative healing quality. According to macroscopic examination, extent of granulations was smaller in the treatment group (dexamethasone: median 0 [95% confidence interval: 0.1-0.6]) than the silicone group (2 [1.5-2.3]; P <= .05). Epithelial wound healing was complete in all specimens, whereas the stroma was significantly thinner in the dexamethasone-group (44 [37-60]; 178 [148-214]). Improved healing quality was achieved significantly more often on the treatment, than on the control side. Scanning electron microscopy revealed no difference between both groups. Conclusions: Using a new drug-releasing stent system, dexamethasone efficiently decreases granulation formation and stroma thickness without impeding epithelial differentiation. Therefore, the use of this system may be of value to decrease restenosis rates in selected patients after frontal sinus surgery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FRONTAL-SINUS; BACTERIAL BIOFILMS; LOTHROP PROCEDURE; RESTENOSIS; SURGERY; MODEL; Wound healing; endoscopic sinus surgery; frontal sinusitis; corticosteroids; stent; treatment outcome; animal study |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Oct 2020 07:09 |
| Last Modified: | 21 Oct 2020 07:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30124 |
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