Calis, Ihsan and Barbic, Matej and Juergenliemk, Guido (2008) Bioactive Cycloartane-Type Triterpene Glycosides from Astragalus elongatus. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 63 (11-12). pp. 813-820. ISSN 0939-5075, 1865-7125
Full text not available from this repository. (Request a copy)Abstract
Together with two known cycloartane-type glycosides, askendosides D(3-O-[alpha-arabino-pyranosyl-(1 -> 2)-beta-xylopyranosyl]-6-O-beta-xylopyranosyl-cycloastragenol, 2) and G (3-O-[alpha-arabinopyranosyl-(1 -> 2)-beta-xylopyranosyl]-16-0-beta-glucopyranosyl-3 beta,6 alpha,16 beta,24(R),25-pentahydroxycycloartane, 3), also a new monodesmosidic cycloartane-type glycoside, elongatoside (1), was isolated from the roots of Astragalits elongatus and identified as 3-O-[alpha-arabinopyranosyl-(1 -> 2)-beta-xylopyranosy]-cycloastragenol. All structures were unambiguously determined by means of spectroscopic and spectrometric methods (1D and 2D NMR, ESI-MS). The isolated compounds were tested for the inhibition of proliferation and ICAM-1 expression in vitro using the human microvascular endothelial cell line (HMEC-1). 1 showed weak activity in the ICAM-1 assay.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LYMPHOCYTE-PROLIFERATION; GENINS; MODULATORS; SAPONINS; CELLS; Astragalus elongatus; Cycloartane-Type Glycosides; Endothelium |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Oct 2020 09:37 |
| Last Modified: | 21 Oct 2020 09:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30153 |
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