Lehle, Karla and Kroher, Johannes and Kolat, Philipp and von Suesskind-Schwendi, Marietta and Schmid, Christof and Haneya, Assad and Rupprecht, Leopold and Hirt, Stephan (2016) Existence of circulating anti-endothelial cell antibodies after heart transplantation is associated with post-transplant acute allograft rejection. HEART AND VESSELS, 31 (5). pp. 752-757. ISSN 0910-8327, 1615-2573
Full text not available from this repository. (Request a copy)Abstract
Anti-endothelial cell antibodies (AECA) may be involved in the development of heart allograft rejection. Its detection might be a cheap and noninvasive method to identify high-risk patients. An indirect immunofluorescence method on human umbilical vein endothelial cells was used to investigate the presence of AECAs in 260 pre- and post-transplant serum samples sequentially collected from 34 patients within the first year after heart transplantation (HTX). The presence of AECAs before (23.5 %) and early after HTX (14.7 %) was associated with a significantly increased risk of early acute rejection (75 and 60 %, respectively) compared to 33 % in AECA-negative patients (p = 0.049). Moreover, rejections from AECA-positive patients were more severe (p = 0.057) with a significantly increased incidence of multiple (p = 0.025). The mean number of the sum of rejection episodes was significantly higher in AECA-positive patients (p a parts per thousand currency sign 0.05). Patients free of AECAs mainly received mycophenolate mofetil as primary immunosuppression (p = 0.067). Nevertheless, the presence of AECAs did not affect long-term outcome and mortality of HTX patients. Despite a low number of patient samples, the detection of AECAs before and early after HTX could be used as a biomarker for an increased risk of early acute rejection in high-risk patients. This easy method might be a valuable tool to support screening procedures to improve individualized immunosuppressive therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VASCULAR ENDOTHELIAL-CELLS; CORONARY-ARTERY-DISEASE; CARDIAC TRANSPLANTATION; MYCOPHENOLATE-MOFETIL; ANTIVIMENTIN ANTIBODIES; CLINICAL-SIGNIFICANCE; VASCULOPATHY; RECIPIENTS; DIAGNOSIS; Early allograft rejection; AECA; Indirect immunofluorescence; Biomarker |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2019 08:21 |
| Last Modified: | 25 Mar 2019 08:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3018 |
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