Treeck, Oliver and Lattrich, C. and Juhasz-Boess, I. and Buchholz, S. and Pfeiler, G. and Ortmann, O. (2008) Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells. BRITISH JOURNAL OF CANCER, 99 (8). pp. 1246-1250. ISSN 0007-0920,
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Serum levels of adiponectin are inversely associated with breast cancer risk. In this study, its effect on growth and gene expression of MCF-7 breast cancer cells and MCF-10A human mammary epithelial cells was compared. The antiproliferative effect of adiponectin on MCF-10A cells was more pronounced and was accompanied by elevated transcript levels of caspase 1, ER beta 2, ER beta 5, TR2 and USP2. Our data suggest that upregulation of genes with known growth inhibitory or apoptotic functions in mammary epithelial cells might contribute to the protective action of this adipocytokine.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ESTROGEN-RECEPTOR-BETA; MESSENGER-RNA EXPRESSION; TR2 ORPHAN RECEPTOR; SERUM ADIPONECTIN; APOPTOSIS; GROWTH; ALPHA; RISK; PCR; IDENTIFICATION; adiponectin; mammary epithelial cell; breast cancer cell line; gene regulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Oct 2020 10:42 |
| Last Modified: | 21 Oct 2020 10:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30180 |
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