Gerbitz, Armin and Hillemanns, Patrick and Schmid, Christoph and Wilke, Andrea and Jayaraman, Rajshri and Kolb, Hans-Jochem and Eissner, Gunther and Holler, Ernst (2008) Influence of polymorphism within the heme oxygenase-I promoter on overall survival and transplantation-related mortality after allogeneic stem cell transplantation. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 14 (10). pp. 1180-1189. ISSN 1083-8791,
Full text not available from this repository. (Request a copy)Abstract
Aside from major and minor histocompatibility antigens, genetic polymorphisms of various donor and host genes have been found to be risk factors for graft-yersus-host disease and transplantation-related mortality (TRM). The heme oxygenase I (HO-I) protein has been implicated in regulating inflammatory response and has been described as a "protective gene" in solid organ transplantation. In humans, the promoter region displays length polymorphism due to a variable number of GT repeats. Individuals exhibiting 29 or fewer GT repeats express higher levels of HO-I on cellular stress compared with individuals with 30 or more GT repeats. We retrospectively analyzed length polymorphisms of 92 donor-host pairs undergoing allogeneic stem cell transplantation. Our findings demonstrate that mainly donor polymorphism leading to high expression of HO-I (<30 GT repeats) on stress signals is associated with reduced overall survival, and that TRM is significantly increased in this group. This reduction in survival was most prominent when unrelated donors were used. Polymorphisms of the recipient HO-I genes did not influence posttransplantation outcomes. We conclude that HO-I polymorphism represents a new genetic risk factor for TRM and overall survival.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; CHRONIC MYELOID-LEUKEMIA; MICROSATELLITE POLYMORPHISM; GENE PROMOTER; GASTROINTESTINAL-TRACT; INDUCED APOPTOSIS; INTERFERON-GAMMA; PROTECTIVE GENE; GRAFT; heme oxygenase; graft-versus-host disease; polymorphism; stem cell transplantation; risk factor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Oct 2020 07:58 |
| Last Modified: | 22 Oct 2020 07:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30193 |
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