Andree, H. and Hilgendorf, I. and Leithaeuser, M. and Junghanss, C. and Holzhueter, S. and Loddenkemper, C. and Steiner, B. and Freund, M. and Wolff, D. (2008) Enteral budesonide in treatment for mild and moderate gastrointestinal chronic GVHD. BONE MARROW TRANSPLANTATION, 42 (8). pp. 541-546. ISSN 0268-3369,
Full text not available from this repository. (Request a copy)Abstract
Budesonide (BUD) is a steroid with a low bioavailability, which has been used for the treatment of oral manifestations of chronic GVHD (cGVHD). We retrospectively evaluated the efficacy of BUD in the treatment of gastrointestinal cGVHD. Thirteen patients (median age 47 years) receiving BUD for the treatment of cGVHD after allogeneic hematopoietic SCT for hematological malignancies were evaluated for response. Five patients had isolated gastrointestinal cGVHD and 8 patients had mild multiorgan involvement including gastrointestinal manifestations. Six patients received CYA at the time of onset of cGVHD, which was continued during treatment with BUD. Treatment consisted of BUD, with an initial daily dose of 3 x 3mg orally. Complete resolution of cGVHD was achieved in seven patients, and one patient achieved partial remission of cGVHD. One patient achieved complete resolution of gastrointestinal cGVHD, while systemic manifestations of cGVHD remained stable. Four patients progressed on BUD. Owing to the predominantly local effect, relapse of symptoms of cGVHD after withdrawal of immunosuppression (n = 3) as well as progression of GVHD at other sites (n = 3) has been observed. BUD represents a treatment option in mild-to-moderate cGVHD, which is well tolerated and associated with a high response rate in gastrointestinal cGVHD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; ORAL BECLOMETHASONE DIPROPIONATE; CONSENSUS DEVELOPMENT PROJECT; STEM-CELL TRANSPLANTATION; WORKING GROUP-REPORT; CHRONIC GRAFT; INTESTINAL GRAFT; CONDITIONING REGIMEN; CONTROLLED-TRIAL; CLINICAL-TRIALS; allogeneic hematopoietic SCT; budenoside; topical steroids; GVHD |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Oct 2020 08:05 |
| Last Modified: | 22 Oct 2020 08:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30196 |
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