Wuelbeck, Corinna and Grieshaber, Eva and Helfrich-Foerster, Charlotte (2008) Pigment-dispersing factor (PDF) has different effects on Drosophila's circadian clocks in the accessory medulla and in the dorsal brain. JOURNAL OF BIOLOGICAL RHYTHMS, 23 (5). pp. 409-424. ISSN 0748-7304, 1552-4531
Full text not available from this repository. (Request a copy)Abstract
The neuropeptide pigment-dispersing factor (PDF) is a key transmitter in the circadian clock of Drosophila melanogaster. Here we studied the rhythmic behaviour of neural mutants with modified arborizations of the large PDF neurons. In sine oculis(1) (so(1)) mutants we found a higher density of PDF fibbers in the fly's pacemaker center, the accessory medulla. These flies exhibited a significantly longer period (24.6) than control flies. When PDF levels were elevated to very high levels in the dorsal brain as true for so(mda) mutants and small optic lobes;so(1) double mutants (sol(1);so(1)), a short-period component split off the long period in behavioral rhythmicity. The short period became shorter the higher the amount of PDF in this brain region and reached a value of similar to 21h. The period alterations were clearly dependent on PDF, because so(1);Pdf(01) and so(mda);Pdf(01) double mutants showed a single free-running component with a period similar to Pdf(0). mutants (similar to 22.5h) and significantly longer than the short period of so(mda) mutants. These observations indicate that PDF feeds back on the clock neurons and changes their period. Obviously, PDF lengthens the period of some clock neurons and shortens that of others.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HORMONE-IMMUNOREACTIVE NEURONS; DEVELOPING OPTIC LOBES; PACEMAKER NEURONS; LATERAL NEURONS; SINE OCULIS; FUNCTIONAL-ANALYSIS; BEHAVIORAL RHYTHMS; NERVOUS-SYSTEM; VISUAL-SYSTEM; GENE; pigment dispersing factor; internal desynchronization; neural muntants; accessory medulla |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Alumni or Retired > Organisation der inneren Uhr auf neuronaler Ebene (Prof. Dr. Charlotte Förster) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Oct 2020 10:24 |
| Last Modified: | 22 Oct 2020 10:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30224 |
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