Markus, Marcello Ricardo Paulista and Stritzke, Jan and Lieb, Wolfgang and Mayer, Bjoern and Luchner, Andreas and Doering, Angela and Keil, Ulrich and Hense, Hans-Werner and Schunkert, Heribert (2008) Implications of persistent prehypertension for ageing-related changes in left ventricular geometry and function: The MONICA/KORA Augsburg study. JOURNAL OF HYPERTENSION, 26 (10). pp. 2040-2049. ISSN 0263-6352, 1473-5598
Full text not available from this repository. (Request a copy)Abstract
Background It is unclear whether persistent prehypertension causes structural or functional alterations of the heart. Methods We examined echocardiographic data of 1005 adults from a population-based survey at baseline in 1994/1995 and at follow-up in 2004/2005. We compared individuals who had either persistently normal (< 120 mmHg systolic and <80 mmHg diastolic, n = 142) or prehypertensive blood pressure (120-139 mmHg or 80-89 mmHg, n = 119) at both examinations using multivariate regression modeling. Results Over 10 years, left ventricular end-diastolic diameters were stable and did not differ between the two groups. However, the prehypertensive blood pressure group displayed more pronounced ageing-related increases of left ventricular wall thickness (+4.7 versus +11.9%, P < 0.001) and left ventricular mass (+8.6 versus +15.7%, P = 0.006). Prehypertension was associated with a raised incidence of left ventricular concentric remodeling (adjusted odds ratio 10.7, 95% confidence interval 2.82-40.4) and left ventricular hypertrophy (adjusted odds ratio 5.33, 1.58-17.9). The ratio of early and late diastolic peak transmitral flow velocities (E/A) decreased by 7.7% in the normal blood pressure versus 15.7% in the prehypertensive blood pressure group (P = 0.003) and at follow-up the ratio of early diastolic peak transmitral flow and early diastolic peak myocardial relaxation velocities (E/EM) was higher (9.1 versus 8.5, P = 0.031) and left atrial size was larger (36.5 versus 35.3 mm, P = 0.024) in the prehypertensive blood pressure group. Finally, the adjusted odds ratio for incident diastolic dysfunction was 2.52 (1.01-6.31) for the prehypertensive blood pressure group. Conclusions Persistent prehypertension accelerates the development of hypertrophy and diastolic dysfunction of the heart.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POPULATION-BASED SAMPLE; BLOOD-PRESSURE; HEART-FAILURE; CARDIOVASCULAR-DISEASE; HYPERTENSIVE PATIENTS; PHYSICAL-ACTIVITY; SYSTOLIC FUNCTION; YOUNG-ADULTS; RISK FACTOR; BODY-SIZE; diastolic dysfunction; echocardiography; left ventricular concentric remodeling; left ventricular hypertrophy; population-based study; prehypertension; risk factors |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Oct 2020 11:55 |
| Last Modified: | 22 Oct 2020 11:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30232 |
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