Lieb, Wolfgang and Zeller, Tanja and Mangino, Massimo and Goetz, Anika and Braund, Peter and Wenzel, Juergen J. and Horn, Christian and Proust, Carole and Linsel-Nitschke, Patrick and Amouyel, Philippe and Bruse, Petra and Arveiler, Dominique and Koenig, Inke R. and Ferrieres, Jean and Ziegler, Andreas and Balmforth, Anthony J. and Evans, Alun and Ducimetiere, Pierre and Cambien, Francois and Hengstenberg, Christian and Stark, Klaus and Hall, Alistair S. and Schunkert, Heribert and Blankenberg, Stefan and Samani, Nilesh J. and Erdmann, Jeanette and Tiret, Laurence (2008) Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction. JOURNAL OF MOLECULAR MEDICINE-JMM, 86 (10). pp. 1163-1170. ISSN 0946-2716,
Full text not available from this repository. (Request a copy)Abstract
Coronary artery disease (CAD) and myocardial infarction (MI) have a genetic basis, but the precise genetic underpinning remains controversial. Recently, an association of the LRP8 R952Q polymorphism (rs5174) with familial premature CAD/MI was reported. We analysed rs5174 (or the perfect proxy rs5177) in 1,210 patients with familial MI and 1,015 controls from the German MI Family study, in 1,926 familial CAD (1,377 with MI) patients and 2,938 controls from the Wellcome Trust Case Control Consortium (WTCCC) MI/CAD cohort, in 346 CAD patients and 351 controls from the AtheroGene study and in 295 men with incident CAD and 301 controls from the Prospective Epidemiological Study of MI study and found no evidence for association in any of the populations studied. In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY-ARTERY-DISEASE; POPULATION; LOCUS; myocardial infarction; coronary artery disease; genetics; polymorphism; LRP8 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Oct 2020 12:01 |
| Last Modified: | 22 Oct 2020 12:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30236 |
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