Bhat, Krishna P. and Pelloski, Christopher E. and Zhang, Yujian and Kim, Se Hoon and deLaCruz, Clarissa and Rehli, Michael and Aldape, Kenneth D. (2008) Selective repression of YKL-40 by NF-kappa B in glioma cell lines involves recruitment of histone deacetylase-1 and-2. FEBS LETTERS, 582 (21-22). pp. 3193-3200. ISSN 1873-3468,
Full text not available from this repository. (Request a copy)Abstract
Here we show that in contrast to other cancer types, tumor necrosis factor (TNF)-alpha suppresses YKL-40 expression in glioma cell lines in a nuclear factor kappa B (NF-kappa B) dependent manner. Even though TNF-alpha causes recruitment of p65 and p50 subunits of NF-kappa B to the YKL-40 promoter in all cell types, recruitment of histone deacetylases (HDAC)-1 and -2, and a consequent deacetylation of histone H3 at the YKL-40 promoter occurs only in glioma cells. Importantly, using chromatin immunoprecipitation assays in frozen glioblastoma multiforme tissues, we show that YKL-40 levels decrease consistent with HDAC1 recruitment despite high levels of nuclear p-p65. This study presents a paradigm for NF-kappa B regulation of one of its targets in a strict cell type specific manner. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NECROSIS-FACTOR-ALPHA; ARTICULAR CHONDROCYTES; NEGATIVE REGULATION; PROTEIN-KINASE; TNF-ALPHA; GENE; EXPRESSION; PATHWAYS; GLIOBLASTOMA; CHI3L1; YKL-40; NF-kappa B; glioma; HDAC |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 06:10 |
| Last Modified: | 26 Oct 2020 06:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30269 |
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