Schober, Katrin and Zhang, Hongxia and Gschwind, Ruth M. (2008) Temperature-dependent interconversion of phosphoramidite-Cu complexes detected by combined diffusion studies, P-31 NMR, and low-temperature NMR spectroscopy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130 (37). pp. 12310-12317. ISSN 0002-7863,
Full text not available from this repository. (Request a copy)Abstract
For copper-catalyzed enantioselective conjugate additions, knowledge about the precatalytic and catalytic complexes has not yet been sufficiently developed to understand the strong influence of different temperatures on these famous reactions. Therefore, NMR experiments with four Cu(I) salts and two phosphoramidite ligands have been performed to elucidate the temperature dependence and the low-temperature structures of these copper complexes. The existence of the precatalytic binuclear complex with a mixed trigonal/tetrahedral coordination on copper is for the first time proven with direct NMR spectroscopic methods. Below 200 K, intermolecular interactions between free ligands and [Cu2X2L3] complexes induce binuclear [Cu2X2L4] complexes similar to the crystal structures. By combining diffusion experiments and P-31 integrals at different temperatures, it is for the first time possible to follow the formation of stoichiometrically different complexes, even under experimental conditions in which the P-31 signals of the complexes are spectroscopically not resolved due to exchange processes. This allows a first correlation between the complex species observed and the synthetic conditions reported. Furthermore, different preferences to build homo- or heterochiral complexes are detected for binaphthol and biphenol phosphoramidite complexes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CATALYZED CONJUGATE ADDITION; ASYMMETRIC ALLYLIC SUBSTITUTION; DIALKYLZINC REAGENTS; COPPER-COMPLEXES; CRYSTAL-STRUCTURE; DIETHYL-ETHER; LIGANDS; AGGREGATION; ALKYLATION; ENONES; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. Ruth Gschwind |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 06:23 |
| Last Modified: | 26 Oct 2020 06:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30277 |
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