Stroebel, Philipp and Moritz, Regina and Leite, Maria Isabel and Willcox, Nick and Chuang, Wen-Yu and Gold, Ralf and Nix, Wilfred and Schalke, Berthold and Kiefer, Reinhard and Mueller-Hermelink, Hans-Konrad and Jaretzki, Alfred and Newsom-Davis, John and Marx, Alexander (2008) The ageing and myasthenic thymus: A morphometric study validating a standard procedure in the histological workup of thymic specimens. JOURNAL OF NEUROIMMUNOLOGY, 201. pp. 64-73. ISSN 0165-5728,
Full text not available from this repository. (Request a copy)Abstract
The thymus is believed to play an important role in the pathogenesis of myasthenia gravis (MG). The 80% of MG patients with anti-acetylcholine receptor autoantibodies fall into three clinical Subgroups: 1) thymoma; 2) early-onset MG (<age of 40: EOMG) and 3) late-onset (LOMG; onset after 40). Thymectomy is widely used in EOMG, but its benefits have not been established in randomized controlled trials. A Multicenter international trial (MGTX) currently seeks to determine whether thymectomy reduces corticosteroid requirements, and to look for Correlations with thymic histology. We here describe the validated, standardized histological workup and reporting System used in this trial. (C) 2008 Elsevier B.V All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACETYLCHOLINE-RECEPTOR; T-CELLS; B-CELLS; CLINICOIMMUNOLOGICAL CHARACTERISTICS; GRAVIS THYMUS; MYOID CELLS; THYMECTOMY; THYMOMA; IMMUNOSENESCENCE; ANTIBODIES; Thymus; Myasthenia gravis; Autoimmunity; Thymectomy Atrophy; Ageing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 06:40 |
| Last Modified: | 26 Oct 2020 06:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30284 |
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