Miklos, Sandra and Mueller, Gunnar and Chang, Yayi and Schubert, Thomas E. O. and Holler, Ernst and Hildebrandt, Gerhard C. (2008) Pulmonary function changes in experimental graft-versus-host disease of the lung. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 14 (9). pp. 1004-1016. ISSN 1083-8791,
Full text not available from this repository. (Request a copy)Abstract
Pulmonary graft-versus-host disease (p-GVHD) is a serious complication after allogeneic stem cell transplantation (allo-SCT) of high morbidity and high mortality. We characterized breathing patterns and pulmonary function changes in correlation to lung histopathology and survival by using a well-established murine model of p-GVHD. Lethally irradiated B6D2F1 mice received SCT from either syngeneic B6D2F1 or allogeneic C57BL/6 animals. Within 6 weeks, severe p-GVHD developed in allogeneic recipients characterized by progressive interstitial, alveolar, peribronchial, and periluminal inflammatory cell infiltration, whereas in syngeneic recipients lung histology remained normal. Allogeneic recipients demonstrated decreased minute ventilation (MV), reduced peak inspiratory and expiratory flow rates as early as 1 week after SCT. In addition, allo-SCT resulted in restrictive pulmonary function changes as early as 7 days after transplantation and in progressive airflow obstruction within 6 weeks. Decreased breathing abilities and pulmonary function changes of allogeneic recipients were associated with increased mortality and the severity of acute graft-versus-host disease (aGVHD). These findings show that p-GVHD can be characterized by changes in pulmonary function and functional respiratory insufficiency. Furthermore, our data strengthen the understanding, that the lung is a critical target organ of aGVHD. (C) 2008 American Society for Blood and Marrow Transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW-TRANSPLANTATION; IDIOPATHIC PNEUMONIA SYNDROME; STEM-CELL TRANSPLANTATION; SURFACTANT PROTEIN-A; EARLY PROINFLAMMATORY EVENTS; SIGNIFICANTLY CONTRIBUTES; BRONCHIOLITIS-OBLITERANS; INTERSTITIAL PNEUMONITIS; INJURY; RECEPTOR; allogeneic stem cell transplantation; lung; graft-versus-host disease; pulmonary function; restrictive; obstructive |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 08:52 |
| Last Modified: | 26 Oct 2020 08:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30319 |
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