Melnik, Bodo and Schmitz, Gerd (2008) FGFR2 signaling and the pathogenesis of acne. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 6 (9). pp. 721-728. ISSN 1610-0379,
Full text not available from this repository. (Request a copy)Abstract
Acne in Apert syndrome and unilateral segmental acneiform nevus are associated with mutations of fibroblast growth factor receptor 2 (FGFR2), which are likely to be involved in the pathogenesis of acne. Translational animal and cellular models, developmental biology studies and clinical observations have contributed to our understanding of FGF-FGFR2 signaling in the pilosebaceous follicle. The importance of FGF-FGFR2 signaling in mesenchymal-epithelial interaction for skin appendage formation, pilosebaceous follicle homeostasis, comeclogenesis and sebaceous gland proliferation is explored. Overstimulation of FGFR2 signaling with increased expression of interleukin-1 alpha explains acne in Apert syndrome und nevus comedonicus. Androgen-mediated up-regulation of FGFR2 signaling could be the initiating signal in the pathogenesis of acne. The gain of function FGFR2 mutations in Apert syndrome and unilateral acneiform nevus are most helpful model diseases for uncovering the fundamental process of androgen-dependent mesenchymal-epithelial FGF-FGFR2 signaling in acne in Apert syndrome, nevus comedonicus and acne vulgaris.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LIGAND-BINDING SPECIFICITY; KERATINOCYTE GROWTH-FACTOR; APERT-SYNDROME; NEVUS COMEDONICUS; SEBACEOUS GLANDS; ANDROGEN RECEPTOR; SONIC-HEDGEHOG; EXPRESSION; SKIN; GENE; acne vulgaris; Apert syndrome; FGF-FGFR2-signaling; interleukin-1 alpha; nevus comedonicus; sonic hedgehog; unilateral acneiform nevus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 08:06 |
| Last Modified: | 26 Oct 2020 08:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30383 |
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