Schwarz, Stephan and Butz, Martin and Morsczeck, Christian and Reichert, Torsten E. and Driemel, Oliver (2008) Increased number of CD25(+) FoxP3(+) regulatory T cells in oral squamous cell carcinomas detected by chromogenic immunohistochemical double staining. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 37 (8). pp. 485-489. ISSN 0904-2512,
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND: The role of tumor-infiltrating regulatory T cells (Treg) compromising antitumor effects of immune cells in oral squamous cell carcinoma (OSCC) is largely unknown. PURPOSE: The presence of CD25(+) FoxP3(+) Treg as well as of CD3(+) FoxP3(+) and of CD8(+) FoxP3(+) tumor-infiltrating lymphocytes (TIL) was verified in OSCC and compared with non-cancerous lymphoepithelial tissue. RESULTS: Three double stainings (CD3/FoxP3, CD8/FoxP3 and CD25/FoxP3) were performed on tissue sections of 15 OSCC and compared with 15 human tonsils. RESULTS: OSCC biopsy samples provide evidence for a strong infiltration of TIL, in particular, naturally occurring CD25(+) FoxP3(+) Treg. Whereas a comparison of OSCC and control tissue did not show significant changes in the number of CD3(+) FoxP3(+) TIL and of CD8(+) FoxP3(+) TIL, a significantly higher frequency of CD25(+) FoxP3(+) TIL (Treg) could be observed in OSCC (P < 0.001, two-sided t-test). Given the small number of specimens, a significant correlation with tumor stage could not be verified. CONCLUSION: Chromogenic double staining of CD4/FoxP3 is a promising tool for the detection of Treg in paraffin-embedded tissue of OSCC.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMMUNOLOGICAL SELF-TOLERANCE; PERIPHERAL-BLOOD; TUMOR MICROENVIRONMENT; IDENTIFICATION; SUPPRESSION; EXPRESSION; INDUCTION; SURVIVAL; CANCER; HEAD; CD25(+) FoxP3(+) regulatory T cells; double staining; immunohistochemistry; oral squamous cell carcinoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 09:17 |
| Last Modified: | 26 Oct 2020 09:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30394 |
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