Bentink, S. and Wessendorf, S. and Schwaenen, C. and Rosolowski, M. and Klapper, W. and Rosenwald, A. and Ott, G. and Banham, A. H. and Berger, H. and Feller, A. C. and Hansmann, M-L and Hasenclever, D. and Hummel, M. and Lenze, D. and Moeller, P. and Stuerzenhofecker, B. and Loeffler, M. and Truemper, L. and Stein, H. and Siebert, R. and Spang, Rainer (2008) Pathway activation patterns in diffuse large B-cell lymphomas. LEUKEMIA, 22 (9). pp. 1746-1754. ISSN 0887-6924,
Full text not available from this repository. (Request a copy)Abstract
Deregulation of cell signaling pathways controlling cell growth and cell survival is a common feature of all cancers. Although a core repertoire of oncogenic mechanisms is widely conserved between various malignancies, the constellation of pathway activities can vary even in patients with the same malignant disease. Modern molecularly targeted cancer drugs intervene in cell signaling compensating for pathway deregulation. Hence characterizing tumors with respect to pathway activation will become crucial for treatment decisions. Here we have used semi-supervised machine learning methodology to generate signatures of eight oncogene-inducible pathways, which are conserved across epithelial and lymphoid tissues. We combined them to patterns of pathway activity called PAPs for pathway activation patterns and searched for them in 220 morphologically, immunohistochemically and genetically well-characterized mature aggressive B-cell lymphomas including 134 cases with clinical data available. Besides Burkitt lymphoma, which was characterized by a unique pattern, the PAPs identified four distinct groups of mature aggressive B-cell lymphomas across independent gene expression studies with distinct biological characteristics, genetic aberrations and prognosis. We confirmed our findings through cross-platform analysis in an independent data set of 303 mature aggressive B-cell lymphomas.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE-EXPRESSION; MOLECULAR DIAGNOSIS; BURKITTS-LYMPHOMA; HODGKIN LYMPHOMA; FOXP1; SURVIVAL; HYBRIDIZATION; SIGNATURES; SUBGROUPS; PROFILES; lymphoma; oncogenic pathways; transcriptional modules; cancer |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 09:39 |
| Last Modified: | 26 Oct 2020 09:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30402 |
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