Anders, Sven and Schaumburger, Jens and Schubert, Thomas and Grifka, Joachim and Behrens, Peter (2008) Matrix-associated autologous chondrocyte transplantation (MACT). Minimally invasive technique in the knee. OPERATIVE ORTHOPADIE UND TRAUMATOLOGIE, 20 (3). pp. 208-219. ISSN 0934-6694,
Full text not available from this repository. (Request a copy)Abstract
Objective Repair of localized cartilage defects in the knee. Indications Localized partial or full-thickness cartilage defects in the knee or osteochondral lesions (osteochondritis dissecans (OD]). Contraindications Generalized cartilage defects, osteoarthritis, bacterial and rheumatoid arthritis, uncorrected axis deformities, ligament instability, patella instability, meniscectomy. Surgical Technique Two-step procedure. 1. Diagnostic arthroscopy and cartilage biopsy for cell cultivation. 2. Minimalized arthrotomy. Defect debridement. Autologous cancellous bone grafting in OD. Glueing of the cell-loaded scaffold into the defect. Postoperative Management Early functional rehabilitation with knee orthosis. Partial weight bearing (20 kg) for 6 weeks. Results 50 patients (24 female, 26 male, age 14-44years, mean 30.3 years) with 58 focal cartilage defects (III-IV degrees) of the knee in the medial (n = 32) or lateral condyle (n = 5), patella (n = 14) and/or trochlea (n = 7) underwent matrix-associated autologous chondrocyte implantation (MACI (R)). The mean follow-up was 24 months (21-29 months). The mean defect size was 4.1 cm(2) (1.6-6.1 cm(2)). The Lysholm Score improved from 57.3 to 87.4 points,the DGKKT (German Society of Autologous Cartilage and Bone Cell Transplantation) Score from 55.3 to 85.5 points. Pain on a visual analog scale (VAS) diminished from 5.5 to 2.1, while subjective function enhanced from 4.5 to 7.6. All scores were significant (p < 0.01; t-test). In eleven patients (twelve defects), a second-look arthroscopy revealed a mostly fibrocartilaginous regenerative tissue in 41.7% (5/12) and a mixed fibrous/hyaline regenerative tissue in 33.4% (4/12). 54% (27/50) of the patients estimated their result as excellent, 28% (14/50) as good, 16% as fair, and 2% (1/50) as poor.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 5-YEAR FOLLOW-UP; ARTICULAR-CARTILAGE; DEFECTS; knee; cartilage defect; ostochondritis dissecans; autologous chondrocyte implantation (ACI); scaffold; MACI (R) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 08:22 |
| Last Modified: | 26 Oct 2020 08:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30416 |
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