Jiang, Dongsheng and Yue, Pei Shan Eunice and Drenkard, Daniela and Schwarz, Herbert (2008) Induction of proliferation and monocytic differentiation of human CD34(+) cells by CD137 ligand signaling. STEM CELLS, 26 (9). pp. 2372-2381. ISSN 1066-5099, 1549-4918
Full text not available from this repository. (Request a copy)Abstract
CD137 is a member of the tumor necrosis factor receptor family and is involved in the regulation of activation, proliferation, differentiation, and cell death of leukocytes. Bidirectional signaling exists for the CD137 receptor/ligand system, as CD137 ligand, which is expressed as a transmembrane protein, can also transduce signals into the cells on which it is expressed. In this study, we have identified expression of CD137 in human bone marrow and expression of CD137 ligand on a subset of CD34(+) cells. Cross-linking of CD137 ligand on CD34(+) cells by CD137 ligand agonists induces activation, prolongation of survival, proliferation, and colony formation. CD137 ligand agonists induce differentiation of early hematopoietic progenitor cells to colony-forming units-granulocyte/macrophage and subsequently to monocytes and macrophages but not to dendritic cells. These data uncover a novel function of CD137 and CD137 ligand by showing their participation in the growth and differentiation of hematopoietic progenitor cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FOLLICULAR DENDRITIC CELLS; COLONY-STIMULATING FACTOR; FACTOR RECEPTOR FAMILY; LYMPHOCYTE-ACTIVATION; IMMUNE-RESPONSE; 4-1BB; HEMATOPOIESIS; SURVIVAL; MEMBERS; MICE; hematopoiesis; CD34(+) cells; myeloid; monocytes; CD137 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 08:43 |
| Last Modified: | 26 Oct 2020 08:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30446 |
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