Mueller, Juergen L. and Gaenssbauer, Susanne and Sommer, Monika and Doehnel, Katrin and Weber, Tatjana and Schmidt-Wilcke, Tobias and Hajak, Goeran (2008) Gray matter changes in right superior temporal gyrus in criminal psychopaths. Evidence from voxel-based morphometry. PSYCHIATRY RESEARCH-NEUROIMAGING, 163 (3). pp. 213-222. ISSN 0925-4927,
Full text not available from this repository. (Request a copy)Abstract
Psychopathy according to the PCL-R describes a specific subgroup of antisocial personality disorder with a high risk for criminal relapses. Lesion and imaging studies point towards frontal or temporal brain regions connected with disturbed social behavior, antisocial personality disorder (APD) and psychopathy. Morphologically, some studies described a reduced prefrontal brain volume, whereas others reported on temporal lobe atrophy. To further investigate whether participants with psychopathy according to the Psychopathy Checklist - Revised Version (PCL-R) show abnormalities in brain structure, we used voxel-based morphometry (VBM) to investigate region-specific changes in gray matter in 17 forensic male inpatients with high PCL-R scores (PCL-R > 28) and 17 male control subjects with low PCL-R scores (PCL < 10). We found significant gray matter reductions in frontal and temporal brain regions in psychopaths compared with controls. In particular, we found a highly significant volume loss in the right superior temporal gyrus. This is the first study to show that psychopathy is associated with a decrease in gray matter in both frontal and temporal brain regions, in particular in the right superior temporal gyrus, supporting the hypothesis that a disturbed frontotemporal network is critically involved in the pathogenesis of psychopathy. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTISOCIAL PERSONALITY-DISORDER; LOBE ABNORMALITIES; STRUCTURAL MRI; VOLUME; PERSPECTIVE; EMPATHY; BRAIN; SCHIZOPHRENIA; HIPPOCAMPUS; ALCOHOLISM; psychopathy; frontotemporal network; PCL-R; volume loss; pathogenesis; superior temporal gyrus; voxel-based morphometry; brain structure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Medicine > Abteilung für Forensische Psychiatrie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 09:04 |
| Last Modified: | 26 Oct 2020 09:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30454 |
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