Klapper, Wolfram and Szczepanowski, Monika and Burkhardt, Birgit and Berger, Hilmar and Rosolowski, Maciej and Bentink, Stefan and Schwaenen, Carsten and Wessendorf, Swen and Spang, Rainer and Moeller, Peter and Hansmann, Martin Leo and Bernd, Heinz-Wolfram and Ott, German and Hummel, Michael and Stein, Harald and Loeffler, Markus and Truemper, Lorenz and Zimmermann, Martin and Reiter, Alfred and Siebert, Reiner (2008) Molecular profiling of pediatric mature B-cell lymphoma treated in population-based prospective clinical trials. BLOOD, 112 (4). pp. 1374-1381. ISSN 0006-4971,
Full text not available from this repository. (Request a copy)Abstract
The spectrum of entities, the therapeutic strategy, and the outcome of mature aggressive B-cell non-Hodgkin lymphomas (maB-NHLs) differs between children and adolescents on the one hand and adult patients on the other. Whereas adult maB-NHLs have been studied in detail, data on molecular profiling of pediatric maB-NHLs are hitherto lacking. We analyzed 65 cases of maB-NHL from patients up to 18 years of age by gene expression profiling, matrix comparative genomic hybridization (CGH), fluorescent in situ hybridization (FISH), and immunohistochemistry. The majority of the analyzed pediatric patients were treated within prospective trials (n = 49). We compared this group to a series of 182 previously published cases of adult maB-NHL. Gene expression profiling reclassified 31% of morphologically defined diffuse large B-cell lymphomas as molecular Burkitt lymphoma (mBL). The subgroups obtained by molecular reclassification did not show any difference in outcome in children treated with the NHL-Berlin-Frankfurt-Muenster (BFM) protocols. No differences were detectable between pediatric and adult mBL with regard to gene expression or chromosomal imbalances. This is the first report on molecular profiling of pediatric B-NHL showing mBL to bemuch more prominent in children than suggested by morphologic assessment. Based on molecular profiling mBL is a molecularly homogeneous disease across children and adults.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NON-HODGKIN-LYMPHOMA; CHEMOTHERAPY PLUS RITUXIMAB; FRANKFURT-MUNSTER GROUP; BURKITTS-LYMPHOMA; ADOLESCENTS; CHILDHOOD; CHILDREN; NEOPLASMS; GENDER; IMPACT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 09:38 |
| Last Modified: | 26 Oct 2020 09:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30476 |
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