Weigelt, Karin and Moehle, Christoph and Stempfl, Thomas and Weber, Bernhard and Langmann, Thomas (2008) An integrated workflow for analysis of ChIP-chip data. BIOTECHNIQUES, 45 (2). 131-+. ISSN 0736-6205, 1940-9818
Full text not available from this repository. (Request a copy)Abstract
Although CHIP-chip is a powerful tool for genome-wide discovery of transcription factor target genes, the steps involving raw data analysis, identification of promoters, and correlation with binding sites are still laborious processes, Therefore, we report an integrated workflow for the analysis of promoter tiling arrays with the Genomatix ChipInspector system. We compare this tool with open-source software packages to identify PU.1 regulated genes in mouse macrophages. Our results suggest that ChipInspector data analysis, comparative genomics for binding site prediction, modeling significant facilitate and enhance whole-genome promoter profiling to reveal in vivo sites of transcription factor-DNA interactions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-DNA INTERACTIONS; CHROMATIN IMMUNOPRECIPITATION; TARGET GENES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 10:05 |
| Last Modified: | 26 Oct 2020 10:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30499 |
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