Rosenberg, Jens and Gustafsson, Finn and Remme, Willem J. and Riegger, Guenter A. J. and Hildebrandt, Per Rossen (2008) Effect of beta-blockade and ACE inhibition on B-type natriuretic peptides in stable patients with systolic heart failure. CARDIOVASCULAR DRUGS AND THERAPY, 22 (4). pp. 305-311. ISSN 0920-3206, 1573-7241
Full text not available from this repository. (Request a copy)Abstract
Introduction The long-term effect of beta-blockade on the plasma levels of natriuretic peptides BNP and its N-terminal counterpart, NT-proBNP, as risk markers in heart failure (HF) is obscure. Methods Stable systolic HF patients from the CARMEN study were divided in groups matching their randomised treatment allocation: Carvedilol, enalapril or carvedilol+enalapril. Changes in BNP and NT-proBNP from baseline to 6 months maintenance visit were evaluated in each treatment arm. Furthermore, the prognostic value of BNP and NT-proBNP during monotherapy with carvedilol was assessed with univariate Cox proportional hazards models using a combined endpoint of all cause mortality and cardiovascular hospitalisation. Results NT-proBNP and BNP were significantly reduced after six months treatment with enalapril (NT-proBNP 1,303 to 857 pg/ml (P<0.001), BNP 119 to 85 pg/ml (P<0.001)) or carvedilol+enalapril (NT-proBNP 1,223 to 953 pg/ml (P=0.003), BNP 117 to 93 pg/ml (P=0.01)). In contrast, no change was observed in the carvedilol group (NT-proBNP 907 to 1,082 pg/ml (P=0.06), BNP 114 to 130 pg/ml (P=0.15). The prognostic value of NT-proBNP and BNP was maintained in the carvedilol group (NT-proBNP HR 1.018 95% CI (1.005-1.032), BNP 1.171 (1.088-1.260)). Conclusion Treatment of HF patients with carvedilol alone does not reduce levels of natriuretic peptides, but treatment with enalapril does. Both BNP and NT-proBNP predict death and hospitalisation in HF patients treated with carvedilol for six months. The clinical implication of our results is that NT-proBNP and BNP can be used as risk markers of death and cardiovascular hospitalisations in systolic HF patients receiving carvedilol without ACE inhibition.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIAC-INSUFFICIENCY BISOPROLOL; CONVERTING ENZYME-INHIBITOR; EVALUATION TRIAL CARMEN; NT-PROBNP; PLASMA-LEVELS; DOUBLE-BLIND; THERAPY; CARVEDILOL; ENALAPRIL; MILD; brain natriuretic peptide; adrenergic beta-antagonists; carvedilol; angiotensin-converting enzyme inhibitors; enalapril; prognosis; congestive heart failure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Oct 2020 15:34 |
| Last Modified: | 26 Oct 2020 15:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30502 |
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