Schuetze, Stefan and Tchikov, Vladimir and Schneider-Brachert, Wulf (2008) Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 9 (8). pp. 655-662. ISSN 1471-0072
Full text not available from this repository. (Request a copy)Abstract
The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-kappa B (NF-kappa B) or through activation of the proliferative mitogen-activated protein kinase (MAPK) cascade. Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; SPHINGOMYELINASE-DERIVED CERAMIDE; ACTIVATED PROTEIN-KINASES; FACTOR-INDUCED APOPTOSIS; INDUCED CELL-DEATH; ACID SPHINGOMYELINASE; NEUTRAL SPHINGOMYELINASE; MEDIATED ENDOCYTOSIS; GENE-EXPRESSION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 04 Mar 2021 11:21 |
| Last Modified: | 04 Mar 2021 11:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30553 |
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