Laws, S. M. and Friedrich, P. and Diehl-Schmid, J. and Mueller, J. and Ibach, B. and Baeuml, J. and Eisele, T. and Foerstl, H. and Kurz, A. and Riemenschneider, M. (2008) Genetic analysis of MAPT haplotype diversity in frontotemporal dementia. NEUROBIOLOGY OF AGING, 29 (8). pp. 1276-1278. ISSN 0197-4580,
Full text not available from this repository. (Request a copy)Abstract
The H1 haplotype of the tau gene, MAPT, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal dementia (FTD). We investigated MAPT haplotype diversity, in 171 sporadic FTD and 186 healthy controls individuals, and report no single marker or haplotype association with increased risk or changes in age at onset. These findings do not support an association of MAPT with FTD but do not rule out its association with other tauopathies. (c) 2007 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROGRESSIVE SUPRANUCLEAR PALSY; TAU HAPLOTYPE; ASSOCIATION; DEGENERATION; MUTATIONS; 17Q21; frontotemporal dementia; microtubule-associated protein tau; MAPT |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Oct 2020 05:38 |
| Last Modified: | 28 Oct 2020 05:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30555 |
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