Hutchinson, James A. and Brem-Exner, Beate G. and Riquelme, Paloma and Roelen, Dave and Schulze, Maren and Ivens, Katrin and Grabensee, Bernd and Witzke, Oliver and Philipp, Thomas and Renders, Lutz and Humpe, Andreas and Sotnikova, Anna and Matthaei, Martina and Heumann, Asmus and Goevert, Felix and Schulte, Thilo and Kabelitz, Dieter and Claas, Frans H. J. and Geissler, Edward K. and Kunzendorf, Ulrich and Faendrich, Fred (2008) A cell-based approach to the minimization of immunosuppression in renal transplantation. TRANSPLANT INTERNATIONAL, 21 (8). pp. 742-754. ISSN 0934-0874,
Full text not available from this repository. (Request a copy)Abstract
Five renal transplant recipients were preoperatively treated with transplant acceptance-inducing cells (TAICs) in a Phase-I safety study of TAICs as an adjunct immune-conditioning therapy in living-donor kidney transplantation. Initially, patients received anti-thymocyte globulin induction therapy in combination with tacrolimus and steroid immunosuppression. Over the course of 12 weeks, steroids were withdrawn and tacrolimus therapy was minimized. Three of the five patients were able to tolerate low-dose tacrolimus monotherapy and one patient was withdrawn from all immunosuppression for over 8 months. No acute or delayed adverse events were associated with the infusion of TAICs. Monitoring of the recipient anti-donor reactivity of TAIC-treated patients in mixed lymphocyte cultures demonstrated that, during periods of clinically stable graft function, recipient T-cell proliferation and cytokine secretion in response to stimulation with donor alloantigen was relatively suppressed. Therefore, although the TAIC-II trial did not provide conclusive evidence of a beneficial effect of preoperative TAIC treatment, the results were encouraging because they suggest that TAICs promote a state of alloantigen-specific unresponsiveness, which might allow safe minimization of pharmacological immunosuppression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REGULATORY T-CELLS; TACROLIMUS MONOTHERAPY; ORGAN-TRANSPLANTATION; BLOOD-TRANSFUSIONS; CLINICAL TOLERANCE; STEM-CELLS; RECIPIENTS; INDUCTION; FUTURE; PRETREATMENT; cell-based therapy; macrophage; TAIC; tolerance; transplant |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Oct 2020 06:55 |
| Last Modified: | 28 Oct 2020 06:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30575 |
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