Hutchinson, James A. and Roelen, Dave and Riquelme, Paloma and Brem-Exner, Beate G. and Witzke, Oliver and Philipp, Thomas and Matthaei, Martina and Goevert, Felix and Claas, Frans H. J. and Westphal, Eckhard and Kunzendorf, Ulrich and Geissler, Edward K. and Faendrich, Fred (2008) Preoperative treatment of a presensitized kidney transplant recipient with donor-derived transplant acceptance-inducing cells. TRANSPLANT INTERNATIONAL, 21 (8). pp. 808-813. ISSN 0934-0874,
Full text not available from this repository. (Request a copy)Abstract
This report describes the case of patient FR, a 31-year-old recipient of a living-related kidney transplant from a donor against whom he was presensitized. Seventeen days prior to transplantation, a central venous infusion of transplant acceptance-inducing cells (TAICs) was administered to the patient. During the 27-month follow up, the patient experienced no acute rejection episodes under an immunosuppressive regime comprising anti-thymocyte globulin (ATG) induction, corticosteroids and tacrolimus. In a similar manner to the kidney transplant recipients treated preoperatively with TAICs in a previous study, patient FR achieved a state of donor-specific hypo-responsiveness. Most remarkably, the deliberate preoperative exposure of a sensitized patient to the sensitizing alloantigen did not heighten his response; on the contrary, after TAIC treatment and transplantation, HLA-specific antibodies were no longer detectable. The case of patient FR provides further evidence of the safety of pre-transplantation treatment with TAICs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RENAL-TRANSPLANTATION; ALLOGRAFT RECIPIENTS; BLOOD-TRANSFUSIONS; ANTIBODIES; cell-based immunotherapy; TAIC; tolerance; transplantation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Oct 2020 06:57 |
| Last Modified: | 28 Oct 2020 06:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30576 |
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