Colomb, Julien and Brembs, Bjoern (2016) PKC in motorneurons underlies self learning, a form of motor learning in Drosophila. PEERJ, 4: e1971. ISSN 2167-8359,
Full text not available from this repository. (Request a copy)Abstract
Tethering a fly for stationary flight allows for exquisite control of its sensory input, such as visual or olfactory stimuli or a punishing infrared laser beam, A torque meter measures the turning attempts of the tethered fly around its vertical body axis, By punishing, say, left turning attempts (in a homogeneous environment), one can train a fly to restrict its behaviour to right turning attempts. It was recently discovered that this form of operant conditioning (called operant self-learning), may constitute a form of motor learning in Drosophila. Previous work had shown that Protein Kinase C (PKC) and the transcription factor dFoxP were specifically involved in self-learning, but not in other forms of learning. These molecules are specifically involved in various forms of motor learning in other animals, such as compulsive biting in Aplysia, song-learning in birds, procedural learning in mice or language acquisition in humans. Here we describe our efforts to decipher which PKC gene is involved in self-learning in Drosophila We also provide evidence that motorneurons may be one part of the neuronal network modified during self-learning experiments. The collected evidence is reminiscent of one of the simplest, clinically relevant forms of motor learning in humans, operant reflex conditioning, which also relies on motorneuron plasticity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FLIGHT ORIENTATION; MEMORY TRACES; H-REFLEX; OPERANT; BEHAVIOR; MECHANISMS; PLASTICITY; APLYSIA; PROTEIN; VARIABILITY; Motor learning; Habit; Operant learning; FoxP; Skill learning; Procedural memory; Motor adaptation; Egocentric strategy |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie Biology, Preclinical Medicine > Institut für Zoologie > Neurogenetik (Prof. Dr. Björn Brembs) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 20 Mar 2019 12:27 |
| Last Modified: | 20 Mar 2019 12:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3058 |
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