Dreiseitel, Andrea and Schreier, Peter and Oehme, Anett and Locher, Sanja and Rogler, Gerhard and Piberger, Heidi and Hajak, Goeran and Sand, Philipp G. (2008) Inhibition of proteasome activity by anthocyanins and anthocyanidins. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 372 (1). pp. 57-61. ISSN 0006-291X,
Full text not available from this repository. (Request a copy)Abstract
Recent reports have demonstrated multiple benefits associated with the consumption of berry fruits, including a decreased vulnerability to oxidative stress, reduced ischemic brain damage, protection of neurons from stroke-induced damage and the reversal of age-related changes in brain and behaviour. Berry fruits contain high amounts of anthocyanins, which play a major role as free radical scavengers. The present study addresses proteasome inhibition as a further mechanism by which anthocyanins and their aglycons, the anthocyanidins, may exert health-promoting effects. HL-60 cells were incubated with 19 test substances and inhibition of the chymotrypsin-like enzyme activity was determined in a chemiluminescent assay. Anthocyanins and their aglycons achieved IC50 values ranging from 7.8 mu M for kaempferidinidin and pelargonidin, to 32.4 mu M for delphiniclin. Thus proteasome inhibitory properties of anthocyanins may contribute to their known anticarcinogenic, antioxidative, anti-inflammatory and neuroprotective activities, rationalizing dietary supplementations with anthocyanins in the prevention and treatment of chronic diseases, including neurodegenerative disorders. (C) 2008 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NF-KAPPA-B; BLUEBERRY SUPPLEMENTED DIET; CELL-DEATH; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; FLAVONOID INTAKE; RATS; DISEASE; CANCER; NEUROPROTECTION; proteasome; anthocyanin; anthocyanidin; procyanidin; flavonoid |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Oct 2020 08:00 |
| Last Modified: | 28 Oct 2020 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30612 |
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