Schubert, T. E. O. and Obermaier, F. and Ugocsai, P. and Maennel, D. N. and Echtenacher, B. and Hofstaedter, F. and Haerle, P. (2008) MURINE MODELS OF ANAEMIA OF INFLAMMATION: EXTRAMEDULLARY HAEMATOPOIESIS REPRESENTS A SPECIES SPECIFIC DIFFERENCE TO HUMAN ANAEMIA OF INFLAMMATION THAT CAN BE ELIMINATED BY SPLENECTOMY. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 21 (3). pp. 577-584. ISSN 0394-6320,
Full text not available from this repository. (Request a copy)Abstract
In contrast to humans, mice physiologically exhibit extramedullary haematopoiesis in the spleen. In spite of this crucial species specific difference not much is known about the contribution of extramedullary haematopoiesis to overall erythropoiesis in models of anaemia of inflammation (At). The objective of this study is to characterize murine At with respect to extramedullary haematopoiesis and to develop a model more closely resembling human Al. Three different models of At [caecal ligation and puncture (CLP), collagen induced arthritis (CIA) and DSS induced chronic colitis (DSSC)] were characterized with respect to red blood parameters, iron metabolism and extramedullary haematopoiesis. Arthritic animals were splenectomised to prevent extramedullary haematopoiesis. Anaemia caused by systemic inflammation was found in all three models. Splenic extramedullary haematopoiesis was markedly increased as reflected by increment in spleen weights and increase of the red pulp resulting in increased reticulocyte counts. Splenectomised arthritic animals did not show increased reticulocyte counts indicating that most of the reticulocytes were produced in the spleen. Our results demonstrate that murine At differs from human Al with respect to increased splenic extramedullary haematopoiesis. Our data demonstrate that induction of At in splenectomised mice represents a good way to model human Al.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTRACTED SEPTIC-PERITONITIS; TUMOR-NECROSIS-FACTOR; CHRONIC-DISEASE; INTERFERON-GAMMA; MOUSE MODEL; MICE; PATHOGENESIS; COLITIS; DEXTRAN; anaemia; inflammation; extramedullary haematopoiesis; spleen; mouse |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Immunologie Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Oct 2020 10:04 |
| Last Modified: | 28 Oct 2020 10:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30669 |
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