Vogel, Susanne and Heilmann, Joerg (2008) Synthesis, cytotoxicity, and antioxidative activity of minor prenylated chalcones from Humulus lupulus. JOURNAL OF NATURAL PRODUCTS, 71 (7). pp. 1237-1241. ISSN 0163-3864,
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The minor hop (Humulus lupulus) chalcones 3'-geranylchalconaringenin (3), 5'-prenylxanthohumol (4), flavokawin (5), xanthohumol H (8), xanthohumol C (9), and 1 '',2 ''-dihydroxanthohumol C (10) were synthesized. The non-natural chalcones 3'-geranyl-6'-O-methylchalconaringenin (2), 3'-methylflavokawin (6), and 2'-O-methyl-3'-prenylchalconar-. ingenin (7) were also synthesized. Cytotoxicity was investigated in HeLa cells, and these compounds all had IC(50) values comparable to xanthohumol (8.2-19.2 mu M). The ORAC-fluorescein assay revealed potent antioxidative activity for 7 and 8 with 5.2 and 4.8 Trolox equivalents, respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CANCER-CELL-LINES; XANTHOHUMOL; FLAVONOIDS; L.; HOP; PRENYLFLAVONOIDS; ACTIVATION; APOPTOSIS; SURVIVAL; DEATH; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Oct 2020 11:05 |
| Last Modified: | 28 Oct 2020 11:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/30687 |
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